Journal: 3 Biotech

Article Title: Current methods in structural proteomics and its applications in biological sciences

doi: 10.1007/s13205-011-0037-1

Figure Lengend Snippet: Protein crystallization and automation. a TTP LabTech’s mosquito ® Crystal automates protein crystallography vapor diffusion set-ups, additive screening and microseeding; b TTP LabTech’s mosquito ® LCP: a dedicated instrument for crystallising membrane proteins using lipidic cubic phase screening. The panel highlights the positive displacement syringe, which dispenses the highly viscous lipid mesophases used in the LCP technique into 96-well crystallization plates. ( c and d ) Crystallization plate set up for hanging drop vapor diffusion experiments; e nanoliter sitting drop experiments set up in a 96-well plate. ( Images courtesy of TTP LabTech Ltd, UK )

Article Snippet: For example, crystallization robots such as the Phoenix TM RE (Rigaku Corporation) and the Mosquito ® (TTP Labtech), which can accurately and reproducibly dispense very small volumes (nl in size) into 96-well plates for automated screening and optimization of crystallization conditions, are now commonplace in many laboratories (Fig. ).

Techniques: Crystallization Assay, Diffusion-based Assay, Membrane